Yes, but not all of them. You can only remove buildings from your town by selling them. That goes for:
- townspeople's houses.
- decorations.

BEAR IN MIND that selling houses drops your town's population by the number of people living in them. Also remember that sales cannot be undone.

You can't sell:
- special buildings.
- factories.
- community buildings you build after being requested to do so by townspeople.