The item is guarded by an enemy:

⚔️ If an item appears translucent and an enemy is nearby, it indicates that the enemy is guarding the item.

⚔️ To interact with the item, you must defeat the enemy first. If you're unsure which enemy is guarding it, click on the item to highlight the specific enemy in the location.

A lock icon is displayed above the item:

🔒 If you see a lock icon above an item, click on it to open a tooltip that explains the requirements for unlocking the item.

🔒 You might need to, for example, level up the Guardian or complete a specific task.